LOH can be caused by deletion of genomic DNA regions containing the normal copy of tumor suppressor genes. This phenomenon is often seen in tumors and in the ...
Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...
Loss of heterozygosity (LOH) is defined as the loss of one parent's contribution to the cell, can be caused by direct deletion, deletion due to unbalanced ...
由 CA Nichols 著作 · 2020 · 被引用 70 次 — Loss of heterozygosity (LOH) may generate cancer-specific vulnerabilities by eliminating genetic redundancy in cancer cells. LOH occurs when a ...
由 GL Ryland 著作 · 2015 · 被引用 158 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...
由 GL Ryland 著作 · 2015 · 被引用 158 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...
由 X Zhang 著作 · 2021 · 被引用 31 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of ...
2023年11月15日 — Loss of heterozygosity (LOH) refers to a specific type of genetic mutation during which there is a loss of one normal copy of a gene or a ...
